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Article

Canonical WNT Signaling Regulates the Pituitary Organizer and Pituitary Gland Formation.

Endocrinology - 1 Oct 2017

Osmundsen Allison M, Keisler Jessica L, Taketo M Mark, Davis Shannon W

Abstract excerpt

The pituitary organizer is a domain within the ventral diencephalon that expresses Bmp4, Fgf8, and Fgf10, which induce the formation of the pituitary precursor, Rathke's pouch, from the oral ectoderm. The WNT signaling pathway regulates this pituitary organizer such that loss of Wnt5a leads to an expansion of the pituitary organizer and an enlargement of Rathke's pouch. WNT signaling is classified into canonical...

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Identifiers

PMID: 28938441
DOI: 10.1210/en.2017-00581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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