Increased Wingless ( <i>Wnt</i> ) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

Abstract excerpt

Wingless (Wnt)/β-catenin signaling plays an essential role during normal development, is a critical regulator of stem cells, and has been associated with cancer in many tissues. Here we demonstrate that genetic expression of a degradation-resistant mutant form of β-catenin in early Rathke's pouch (RP) progenitors leads to pituitary hyperplasia and severe disruption of the pituitary-specific transcription factor...

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