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Article

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2008

Potok Mary Anne, Cha Kelly B, Hunt Andrea, Brinkmeier Michelle L, Leitges Michael, Kispert Andreas, Camper Sally A

Abstract excerpt

We examined the role of WNT signaling in pituitary development by characterizing the pituitary phenotype of three WNT knockout mice and assessing the expression of WNT pathway components. Wnt5a mutants have expanded domains of Fgf10 and bone morphogenetic protein expression in the ventral diencephalon and a reduced domain of LHX3 expression in Rathke's pouch. Wnt4 mutants have mildly reduced cell differentiation,...

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Source

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Identifiers

PMID: 18351662
DOI: 10.1002/dvdy.21511
PMCID: PMC2799114

Genes

LHX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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