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Article

Hedgehog signaling is required for pituitary gland development.

Development (Cambridge, England) - 1 Feb 2001

Treier M, O'Connell S, Gleiberman A, Price J, Szeto D P, Burgess R, Chuang P T, McMahon A P, Rosenfeld M G

Abstract excerpt

Pituitary gland development serves as an excellent model system in which to study the emergence of distinct cell types from a common primordium in mammalian organogenesis. We have investigated the role of the morphogen Sonic hedgehog (SHH) in outgrowth and differentiation of the pituitary gland using loss- and gain-of-function studies in transgenic mice. Shh is expressed throughout the ventral diencephalon and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11152636
DOI: 10.1242/dev.128.3.377

Genes

SHH
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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