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Article

CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013

Akhtar Shamima, Gremse Felix, Kiessling Fabian, Weber Christian, Schober Andreas

Abstract excerpt

OBJECTIVE: Unstable atherosclerotic lesions are prone to rupture, which leads to atherothrombosis. Chemokine (C-X-C motif) ligand 12 (CXCL12) promotes the mobilization and neointimal recruitment of smooth muscle progenitor cells (SPCs), and thereby mediates vascular repair. Moreover, treatment with SPCs stabilizes atherosclerotic lesions in mice. We investigated the role of CXCL12 in the treatment of unstable...

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Source

Identifiers

PMID: 23393393
DOI: 10.1161/ATVBAHA.112.301162

Genes

CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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