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Article

Reservoir of Fibroblasts Promotes Recovery From Limb Ischemia

21 Aug 2020

Abstract excerpt

Background: The angiogenic response to ischemia restores perfusion so as to preserve tissue. A role for mesenchymal-to-endothelial transition in the angiogenic response is controversial. This study is to determine if resident fibroblasts contribute to angiogenesis. Methods: We utilized the murine model of hindlimb ischemia, and in vivo Matrigel plug assay together with lineage tracing studies and single cell...

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PMID: 32820662
DOI: 10.1161/circulationaha.120.046872

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