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Article

Structure of the Holliday junction intermediate in Cre-loxP site-specific recombination.

The EMBO journal - 15 Jul 1998

Gopaul D N, Guo F, Van Duyne G D

Abstract excerpt

We have determined the X-ray crystal structures of two DNA Holliday junctions (HJs) bound by Cre recombinase. The HJ is a four-way branched structure that occurs as an intermediate in genetic recombination pathways, including site-specific recombination by the lambda-integrase family. Cre recombinase is an integrase family member that recombines 34 bp loxP sites in the absence of accessory proteins or auxiliary...

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Identifiers

PMID: 9670032
DOI: 10.1093/emboj/17.14.4175
PMCID: PMC1170750

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