Structure of the Holliday junction intermediate in Cre-loxP site-specific recombination.

doi:10.1093/emboj/17.14.4175

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Article

Structure of the Holliday junction intermediate in Cre-loxP site-specific recombination.

The EMBO journal - 15 Jul 1998

Gopaul D N, Guo F, Van Duyne G D

Abstract excerpt

We have determined the X-ray crystal structures of two DNA Holliday junctions (HJs) bound by Cre recombinase. The HJ is a four-way branched structure that occurs as an intermediate in genetic recombination pathways, including site-specific recombination by the lambda-integrase family. Cre recombi...

Topics

Amino Acid Substitution
Binding Sites
Crystallography, X-Ray
DNA
Integrases
Isomerism
Models, Molecular
Mutation
Nucleic Acid Conformation
Oligodeoxyribonucleotides
Protein Conformation
Recombination, Genetic
Repetitive Sequences, Nucleic Acid
Viral Proteins

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