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Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

1 Aug 2008

Abstract excerpt

HIV-1 reverse transcriptase (RT) is a primary target for anti-AIDS drugs. Structures of HIV-1 RT, usually determined at approximately 2.5-3.0 A resolution, are important for understanding enzyme function and mechanisms of drug resistance in addition to being helpful in the design of RT inhibitors. Despite hundreds of attempts, it was not possible to obtain the structure of a complex of HIV-1 RT with TMC278, a...

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PMID: 18676450
DOI: 10.1093/nar/gkn464

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