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Article

Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development.

Genomics - 1 Aug 2011

Sato Shun, Yoshida Wataru, Soejima Hidenobu, Nakabayashi Kazuhiko, Hata Kenichiro

Abstract excerpt

The Dlk1-Dio3 imprinted domain on mouse chromosome 12 contains IG-DMR and Gtl2-DMR, whose methylation patterns are established in the germline and after fertilization, respectively. In this study, we determine that acquisition of DNA methylation at the paternal allele of the Gtl2-DMR is initiated after the blastocyst stage and completed by embryonic day 6.5, and that Gtl2 (approved symbol: Meg3) is...

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Source

Identifiers

PMID: 21620950
DOI: 10.1016/j.ygeno.2011.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development.PMID 21620950Read ↗

Establishment of paternal allele-specific DNA methylation at the imprinted mouse Gtl2 locus.Semantic proximity Read ↗

A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development.Semantic proximity Read ↗

Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene.Semantic proximity Read ↗

Epigenome editing reveals core DNA methylation for imprinting control in the Dlk1-Dio3 imprinted domain.Semantic proximity Read ↗

Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region.Semantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.Semantic proximity Read ↗

The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization periodSemantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the <i>Dlk1-Dio3</i> locusSemantic proximity Read ↗

Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19Semantic proximity Read ↗

Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice.Semantic proximity Read ↗

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1Semantic proximity Read ↗

Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12.Semantic proximity Read ↗

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