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Article

Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM

1 Aug 2004

Abstract excerpt

Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic syndrome apparent in the first weeks of life and again during early adulthood.The relative contributions of reduced islet β cell number and impaired β cell function to the observed hypoinsulinemia are unclear.The inheritance pattern of this imprinted disorder implicates overexpression of one or both genes within the TNDM locus: ZAC, which...

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Share to Epigenetics and DNA Methylation
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PMID: 15286800
DOI: 10.1172/jci19876

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