Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity.

PloS one - 1 Jan 2017

Lundgren Hanna, Martinsson Klara, Cederbrant Karin, Jirholt Johan, Mucs Daniel, Madeyski-Bengtson Katja, Havarinasab Said, Hultman Per

Abstract excerpt

The oral thrombin inhibitor ximelagatran was withdrawn in the late clinical trial phase because it adversely affected the liver. In approximately 8% of treated patients, drug-induced liver injury (DILI) was expressed as transient alanine transaminase (ALT) elevations. No evidence of DILI had been revealed in the pre-clinical in vivo studies. A whole genome scan study performed on the clinical study material...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azetidines
Share to Benzylamines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to HLA-DQ Antigens

Share to HLA-DR7 Antigen

Share to Lymphocytes

Share to Mice, Transgenic

Share to Molecular Docking Simulation

Source

Open in PubMed Open full text

Identifiers

PMID: 28934241
DOI: 10.1371/journal.pone.0184744
PMCID: PMC5608249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity.PMID 28934241Read ↗

Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models.Semantic proximity Read ↗

HLA transgenic mice: application in reproducing idiosyncratic drug toxicity.Semantic proximity Read ↗

Drug-induced liver injury in humans: the case of ximelagatran.Semantic proximity Read ↗

HLA class II transgenic mice as models of human diseasesSemantic proximity Read ↗

[Importance of HLA in Determining Individual Differences in the Onset of Adverse Drug Reactions].Semantic proximity Read ↗

[Recent Insights into HLA-dependent Idiosyncratic Liver Injury].Semantic proximity Read ↗

Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitisSemantic proximity Read ↗

The use of human leucocyte antigen class I transgenic mice to investigate human immune function.Semantic proximity Read ↗

A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivitySemantic proximity Read ↗

CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1.Semantic proximity Read ↗

Selective HLA Class II Allele-Restricted Activation of Atabecestat Metabolite-Specific Human T-Cells.Semantic proximity Read ↗

Spondylarthritis in HLA-B27/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.