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Article

A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivity

21 May 2018

Abstract excerpt

Adverse drug reactions (ADRs) are a major obstacle to drug development, and some of these, including hypersensitivity reactions to the HIV reverse transcriptase inhibitor abacavir (ABC), are associated with HLA alleles, particularly HLA-B*57:01. However, not all HLA-B*57:01+ patients develop ADRs, suggesting that in addition to the HLA genetic risk, other factors may influence the outcome of the response to the...

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PMID: 29782330
DOI: 10.1172/jci99321

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