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Article

HLA transgenic mice: application in reproducing idiosyncratic drug toxicity.

Drug metabolism reviews - 1 Nov 2020

Susukida Takeshi, Aoki Shigeki, Shirayanagi Tomohiro, Yamada Yushiro, Kuwahara Saki, Ito Kousei

Abstract excerpt

Various types of transgenic mice carrying either class I or II human leukocyte antigen (HLA) molecules are readily available, and reports describing their use in a variety of studies have been published for more than 30 years. Examples of their use include the discovery of HLA-specific antigens against viral infection as well as the reproduction of HLA-mediated autoimmune diseases for the development of...

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Identifiers

PMID: 32847422
DOI: 10.1080/03602532.2020.1800725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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