Article
DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding.
Clinical epigenetics - 1 Jan 2017
Zhu Zaihua, Meng Weida, Liu Peiru, Zhu Xiaoxia, Liu Yun, Zou Hejian
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are unknown. This study sought to understand the molecular mechanism of a common genetic variant, rs780093, in the development of gout, both in vitro and in vivo. RESULTS: Nuclear receptor binding...
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