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Computational and functional analyses of T2D GWAS SNPs for transcription factor binding.

Biochemical and biophysical research communications - 12 Mar 2020

Cheng Mengrong, Huang Xinyao, Zhang Manling, Huang Qingyang

Abstract excerpt

Genome-wide association studies (GWASs) have successfully identified numerous non-coding genetic variants for type 2 diabetes (T2D), but the functional roles underlying these non-coding variants remain largely unknown. The effects of T2D GWAS lead SNPs on transcriptional factors binding motifs were firstly analyzed via JASPAR, followed by functional validations including dual-luciferase reporter assays,...

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PMID: 31948755
DOI: 10.1016/j.bbrc.2019.12.086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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