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Article

Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells.

Immunological investigations - 1 Jan 2008

Chen Jibing, Yang Wei, Yu Chunlei, Li Yi

Abstract excerpt

The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmune (non-obese diabetic [NOD]) mouse model express much lower levels of an autoimmune regulator...

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Identifiers

PMID: 18389440
DOI: 10.1080/08820130801967841

Genes

TRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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