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Overview of Transgenic Mouse Models for Alzheimer's Disease

19 Aug 2019

Abstract excerpt

This review describes several transgenic mouse models of Alzheimer's disease (AD), a devastating neurodegenerative disorder that causes progressive cognitive decline and is diagnosed postmortem by the presence of extracellular amyloid-β (Aβ) plaques and intraneuronal tau neurofibrillary tangles in the cerebral cortex. Currently there is no intervention that cures, prevents, or even slows disease progression. Its...

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PMID: 31532917
DOI: 10.1002/cpns.81

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