Article
Functional studies and rare variant screening of SLC1A1/EAAC1 in males with obsessive-compulsive disorder.
Psychiatric genetics - 1 Oct 2012
Veenstra-VanderWeele Jeremy, Xu Tim, Ruggiero Alicia M, Anderson Lauren R, Jones Shaine T, Himle Joseph A, Kennedy James L, Richter Margaret A, Hanna Gregory L, Arnold Paul D
Abstract excerpt
Several studies have found that the neuronal glutamate transporter gene SLC1A1/EAAC1 is associated with obsessive-compulsive disorder (OCD), with a stronger association in males. Previous studies have primarily focused on common single-nucleotide polymorphisms, rather than rare functional variants that are likely to have larger effects. We screened 184 males with OCD for rare variation in SLC1A1 exons; however,...
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