Article
Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2013
Stewart S E, Mayerfeld C, Arnold P D, Crane J R, O'Dushlaine C, Fagerness J A, Yu D, Scharf J M, Chan E, Kassam F, Moya P R, Wendland J R, Delorme R, Richter M A, Kennedy J L, Veenstra-VanderWeele J, Samuels J, Greenberg B D, McCracken J T, Knowles J A, Fyer A J, Rauch S L, Riddle M A, Grados M A, Bienvenu O J, Cullen B, Wang Y, Shugart Y Y, Piacentini J, Rasmussen S, Nestadt G, Murphy D L, Jenike M A, Cook E H, Pauls D L, Hanna G L, Mathews C A
Abstract excerpt
The neuronal glutamate transporter gene SLC1A1 is a candidate gene for obsessive-compulsive disorder (OCD) based on linkage studies and convergent evidence implicating glutamate in OCD etiology. The 3' end of SLC1A1 is the only genomic region with consistently demonstrated OCD association, especially when analyzing male-only probands. However, specific allele associations have not been consistently replicated,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.