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Article

Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster.

Insect science - 1 Feb 2017

Kim Kiyoung, Yoon Jeongsook, Yim Jeongbin, Kim Hyung-Jun

Abstract excerpt

NEDD8 conjugation of Cullin has an important role in ubiquitin-mediated protein degradation. The COP9 signalosome, of which CSN5 is the major catalytic subunit, is a major Cullin deneddylase. Another deneddylase, Deneddylase 1, has also been shown to process the Nedd8 precursor. In Drosophila, the DEN1 mutants do not have increased levels of Cullin neddylation, but instead show a significant decrease in...

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Identifiers

PMID: 26332639
DOI: 10.1111/1744-7917.12274

Genes

NEDD8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster.PMID 26332639Read ↗

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