Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity.

Cancer research - 2 May 2025

Buckenmeyer Michael J, Brooks Elizabeth A, Taylor Madison S, Orenuga Ireolu K, Yang Liping, Holewinski Ronald J, Meyer Thomas J, Galloux Melissa, Garmendia-Cedillos Marcial, Pohida Thomas J, Andresson Thorkell, St Croix Brad, Wolf Matthew T

Abstract excerpt

Three-dimensional (3D) in vitro cell culture models are invaluable tools for investigating the tumor microenvironment. However, analyzing the impact of critical stromal elements, such as extracellular matrix (ECM), remains a challenge. In this study, we developed a hydrogel-free self-assembly platform to establish ECM-rich 3D "MatriSpheres" to deconvolute cancer cell-ECM interactions. Mouse and human colorectal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix

Share to Phenotype

Share to Spheroids, Cellular

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 39888317
DOI: 10.1158/0008-5472.CAN-24-1954
PMCID: PMC12048290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity.PMID 39888317Read ↗

Engineering Tumor Stroma Morphogenesis Using Dynamic Cell-Matrix Spheroid AssemblySemantic proximity Read ↗

Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo.Semantic proximity Read ↗

The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular MatricesSemantic proximity Read ↗

Harnessing Extracellular Matrix Biology for Tumor Drug DeliverySemantic proximity Read ↗

Engineered colorectal cancer tissue recapitulates key attributes of a patient-derived xenograft tumor lineSemantic proximity Read ↗

Tumor-Associated EDA-FN-Enriched Matrix Instructs Macrophage BehaviorSemantic proximity Read ↗

Modeling Tumor Phenotypes In Vitro with Three-Dimensional BioprintingSemantic proximity Read ↗

Recapitulating Patient-to-Patient Colorectal Cancer Tumor Heterogeneity Using Patient-Derived Xenograft Cells in an Engineered Tissue ModelSemantic proximity Read ↗

Differential cellular origins of the extracellular matrix of tumor and normal tissues according to colorectal cancer subtypesSemantic proximity Read ↗

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in CancerSemantic proximity Read ↗

Establishment of a tissue‐engineered colon cancer model for comparative analysis of cancer cell linesSemantic proximity Read ↗

Engineering the Extracellular Matrix to Model the Evolving Tumor MicroenvironmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.