Article

Engineering Tumor Stroma Morphogenesis Using Dynamic Cell-Matrix Spheroid Assembly

2024-03-22

Abstract excerpt

The tumor microenvironment consists of resident tumor cells organized within a compositionally diverse, three-dimensional (3D) extracellular matrix (ECM) network that cannot be replicated in vitro using bottom-up synthesis. We report a new self-assembly system to engineer ECM-rich 3D MatriSpheres wherein tumor cells actively organize and concentrate microgram quantities of decellularized ECM dispersions which modu...

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Identifiers and source

Literature Corpus work: 7716eef2-9d21-5000-8107-7461492b14d8
DOI: 10.1101/2024.03.19.585805

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