Article
Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway.
Gastroenterology - 1 Jan 2018
Chen Jian, Zaidi Sobia, Rao Shuyun, Chen Jiun-Sheng, Phan Liem, Farci Patrizia, Su Xiaoping, Shetty Kirti, White Jon, Zamboni Fausto, Wu Xifeng, Rashid Asif, Pattabiraman Nagarajan, Mazumder Raja, Horvath Anelia, Wu Ray-Chang, Li Shulin, Xiao Cuiying, Deng Chu-Xia, Wheeler David A, Mishra Bibhuti, Akbani Rehan, Mishra Lopa
Abstract excerpt
BACKGROUND & AIMS: Development of hepatocellular carcinoma (HCC) is associated with alterations in the transforming growth factor-beta (TGF-β) signaling pathway, which regulates liver inflammation and can have tumor suppressor or promoter activities. Little is known about the roles of specific members of this pathway at specific of HCC development. We took an integrated approach to identify and validate the...
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