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Article

Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma.

The American journal of surgical pathology - 1 Nov 2017

Sajed Dipti P, Faquin William C, Carey Chris, Severson Eric A, H Afrogheh Amir, A Johnson Carl, Blacklow Stephen C, Chau Nicole G, Lin Derrick T, Krane Jeffrey F, Jo Vickie Y, Garcia Joaquín J, Sholl Lynette M, Aster Jon C

Abstract excerpt

NOTCH1 is frequently mutated in adenoid cystic carcinoma (ACC). To test the idea that immunohistochemical (IHC) staining can identify ACCs with NOTCH1 mutations, we performed IHC for activated NOTCH1 (NICD1) in 197 cases diagnosed as ACC from 173 patients. NICD1 staining was positive in 194 cases (98%) in 2 major patterns: subset positivity, which correlated with tubular/cribriform histology; and diffuse...

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Share to Carcinoma, Adenoid Cystic
Share to Diagnosis, Differential

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to In Situ Hybridization, Fluorescence

Share to Kaplan-Meier Estimate

Share to Predictive Value of Tests

Share to Receptor, Notch1

Share to Salivary Gland Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 28914715
DOI: 10.1097/PAS.0000000000000945
PMCID: PMC5657508

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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