Article

Genetic Profiling in Heterogeneous High-Grade Adenoid Cystic Carcinoma Identifies NOTCH1 Inhibition as a Therapeutic Strategy

2020-11-13

Abstract excerpt

<title>Abstract</title> <p>Background High-grade adenoid cystic carcinomas (ACCs), consisting mostly of the solid type along with the occasional high-grade transformation (ACC-HGT) type, are highly aggressive and heterogeneous tumors. Because of the rarity of the tumors, therapeutic strategy guided by genetic profiles based on next generation sequencing (NGS) has been not published on these tumors. Results Fort...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c720e246-5916-55c0-8330-25485594fecb
DOI: 10.21203/rs.3.rs-104544/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Profiling in Heterogeneous High-Grade Adenoid Cystic Carcinoma Identifies NOTCH1 Inhibition as a Therapeutic StrategyDOI 10.21203/rs.3.rs-104544/v1Read

Genetic Profiling in Heterogeneous High-Grade Adenoid Cystic Carcinoma Identifies NOTCH1 Inhibition as a Therapeutic StrategySemantic proximity Read

Metastatic Adenoid Cystic Carcinoma: Genomic Landscape and Emerging Treatments.Semantic proximity Read

Mutational landscape and clonal diversity of pulmonary adenoid cystic carcinoma.Semantic proximity Read

Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinomaSemantic proximity Read

Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma.Semantic proximity Read

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profilingSemantic proximity Read

Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas.Semantic proximity Read

Genetic profile of adenoid cystic carcinomas (ACC) with high-grade transformation versus solid type.Semantic proximity Read

Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.Semantic proximity Read

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors.Semantic proximity Read

Targeted Molecular Analysis in Adrenocortical Carcinomas: A Strategy Toward Improved Personalized PrognosticationSemantic proximity Read

Integrative Multi-omics Guides PD-1 Blockade Therapy in the Rare and Aggressive Colorectal Adenosquamous CarcinomaSemantic proximity Read