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Article

Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2018

Xie Mian, Wei Shenhai, Wu Xiaojun, Li Xiaoxiang, You You, He Chaosheng

Abstract excerpt

INTRODUCTION: Adenoid cystic carcinoma (ACC) of the trachea lacks of well-characterized molecular markers. There is currently no specific treatment for metastatic ACC of the trachea. This study aimed to identify genomic mutations of Notch pathway and investigate the efficacy of NOTCH inhibitor in ACC of the trachea. METHODS: 73 Patients with ACC of the trachea at four institutions from 2008 to 2016 were...

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Share to Antibodies, Monoclonal
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Adenoid Cystic

Share to Mice, Nude

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Share to Receptor, Notch1

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Source

Identifiers

PMID: 29858025
DOI: 10.1016/j.lungcan.2018.04.020

Genes

NOTCH1
HES1
JAG1
NOTCH2
NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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