Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

doi:10.1158/1078-0432.CCR-20-1192

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Article

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2021

Ferrarotto Renata, Mitani Yoshitsugu, McGrail Daniel J, Li Kaiyi, Karpinets Tatiana V, Bell Diana, Frank Steven J, Song Xingzhi, Kupferman Michael E, Liu Bin, Lee J Jack, Glisson Bonnie S, Zhang Jianhua, Aster Jon C, Lin Shiaw-Yih, Futreal P Andrew, Heymach John V, El-Naggar Adel K

Abstract excerpt

PURPOSE: Salivary gland adenoid cystic carcinoma (ACC) has heterogeneous clinical behavior. Currently, all patients are treated uniformly, and no standard-of-care systemic therapy exists for metastatic ACC. We conducted an integrated proteogenomic analyses of ACC tumors to identify dysregulated pathways and propose a classification with therapeutic implications. EXPERIMENTAL DESIGN: RNA/DNA sequencing of 54...

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PMID: 33172898
DOI: 10.1158/1078-0432.CCR-20-1192
PMCID: PMC7854509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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