Article
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Nucleic acids research - 6 Sept 2017
Nath Sarmi, Somyajit Kumar, Mishra Anup, Scully Ralph, Nagaraju Ganesh
Abstract excerpt
The FANCJ DNA helicase is linked to hereditary breast and ovarian cancers as well as bone marrow failure disorder Fanconi anemia (FA). Although FANCJ has been implicated in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR), the molecular mechanism underlying the tumor suppressor functions of FANCJ remains obscure. Here, we demonstrate that FANCJ deficient human and hamster cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.