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Article

A mutation-resistant deoxyribozyme OR gate for highly selective detection of viral nucleic acids.

Chemical communications (Cambridge, England) - 21 Sept 2017

Kamar Ola, Sun Sin-Cih, Lin Chieh-Hua, Chung Wan-Yu, Lee Min-Shi, Liao Yu-Chieh, Kolpashchikov Dmitry M, Chuang Min-Chieh

Abstract excerpt

Highly selective probes hybridize only to fully complementary DNA or RNA sequences and, therefore, often fail to recognize mutated viral genomes. Here we designed a probe that possesses two seemingly incompatible properties: it tolerates some point mutations in genome, while it remains selective towards others. An OR deoxyribozyme logic gate was designed to fluorescently report the sequences of enterovirus 71...

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Identifiers

PMID: 28900642
DOI: 10.1039/c7cc05576e
PMCID: PMC5645154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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