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PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition

28 Dec 2024

Abstract excerpt

The overexpression of Polo-like kinase 1 (PLK1) is associated with poor clinical outcomes in various malignancies, making it an attractive target for anticancer therapies. Although recent studies suggest PLK1's involvement in homologous recombination (HR), the impact of its overexpression on HR remains unclear. In this study, we investigated the effect of PLK1 overexpression on HR using bioinformatics and...

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PMID: 39732958
DOI: 10.1038/s41598-024-82724-w

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