Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

doi:10.1038/ng.2814

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Article

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

Nature genetics - 1 Dec 2013

Behjati Sam, Tarpey Patrick S, Presneau Nadège, Scheipl Susanne, Pillay Nischalan, Van Loo Peter, Wedge David C, Cooke Susanna L, Gundem Gunes, Davies Helen, Nik-Zainal Serena, Martin Sancha, McLaren Stuart, Goodie Victoria, Robinson Ben, Butler Adam, Teague Jon W, Halai Dina, Khatri Bhavisha, Myklebost Ola, Baumhoer Daniel, Jundt Gernot, Hamoudi Rifat, Tirabosco Roberto, Amary M Fernanda, Futreal P Andrew, Stratton Michael R, Campbell Peter J, Flanagan Adrienne M

Abstract excerpt

It is recognized that some mutated cancer genes contribute to the development of many cancer types, whereas others are cancer type specific. For genes that are mutated in multiple cancer classes, mutations are usually similar in the different affected cancer types. Here, however, we report exquisite tumor type specificity for different histone H3.3 driver alterations. In 73 of 77 cases of chondroblastoma (95%),...

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PMID: 24162739
DOI: 10.1038/ng.2814
PMCID: PMC3839851

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