Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2017

Speca David J, Trimmer James S, Peterson Andrew S, Díaz Elva

Abstract excerpt

The identification of novel genes underlying complex mouse behavioral traits remains an important step in understanding normal brain function and its dysfunction in mental health disorders. To identify dominant mutations that influence locomotor activity, we performed a mouse N-ethyl-N-nitrosourea (ENU) forward mutagenesis screen and mapped several loci as quantitative traits. Here we describe the fine-mapping...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Mammalian
Share to Exome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Membrane Proteins

Share to Mutagenesis

Share to Mutation, Missense

Share to Nerve Tissue Proteins

Share to Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 28894906
DOI: 10.1007/s00335-017-9716-5
PMCID: PMC5702255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL.PMID 28894906Read ↗

Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants.Semantic proximity Read ↗

Chemical mutagenesis induced two high bone density mouse mutants map to a concordant distal chromosome 4 locus.Semantic proximity Read ↗

A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.Semantic proximity Read ↗

Genetic influences on motor learning and superperformance mutants revealed by random mutational survey of mouse locomotionSemantic proximity Read ↗

Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy.Semantic proximity Read ↗

Truncated ASXL3 Alters Chromatin Accessibility and Epigenetic Landscape in Bainbridge-Ropers Syndrome Suggesting a Gain-of-Function EtiologySemantic proximity Read ↗

Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis.Semantic proximity Read ↗

Transcriptional linkage analysis with in vivo AAV-Perturb-seq.Semantic proximity Read ↗

Genetic influences on motor learning and performance and superperforming mutants revealed by random mutational survey of the mouse genome.Semantic proximity Read ↗

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.Semantic proximity Read ↗

C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.Semantic proximity Read ↗

Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.