Article
C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.
Science (New York, N.Y.) - 20 Dec 2013
Kumar Vivek, Kim Kyungin, Joseph Chryshanthi, Kourrich Saïd, Yoo Seung-Hee, Huang Hung Chung, Vitaterna Martha H, de Villena Fernando Pardo-Manuel, Churchill Gary, Bonci Antonello, Takahashi Joseph S
Abstract excerpt
The inbred mouse C57BL/6J is the reference strain for genome sequence and for most behavioral and physiological phenotypes. However, the International Knockout Mouse Consortium uses an embryonic stem cell line derived from a related C57BL/6N substrain. We found that C57BL/6N has a lower acute and sensitized response to cocaine and methamphetamine. We mapped a single causative locus and identified a nonsynonymous...
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