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Article

Genetic influences on motor learning and performance and superperforming mutants revealed by random mutational survey of the mouse genome.

The Journal of physiology - 1 Jun 2024

Jakkamsetti Vikram, Ma Qian, Angulo Gustavo, Scudder William, Beutler Bruce, Pascual Juan M

Abstract excerpt

Evolution depends upon genetic variations that influence physiology. As defined in a genetic screen, phenotypic performance may be enhanced or degraded by such mutations. We set out to detect mutations that influence motor function, including motor learning. Thus, we tested the motor effects of 36,444 non-synonymous coding/splicing mutations induced in the germline of C57BL/6J mice with N-ethyl-N-nitrosourea by...

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Identifiers

PMID: 38299894
DOI: 10.1113/JP285505
PMCID: PMC11142877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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