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Article

Evolution analysis of heterogeneous non-small cell lung carcinoma by ultra-deep sequencing of the mitochondrial genome.

Scientific reports - 11 Sept 2017

Amer Wafa, Toth Csaba, Vassella Erik, Meinrath Jeannine, Koitzsch Ulrike, Arens Anne, Huang Jia, Eischeid Hannah, Adam Alexander, Buettner Reinhard, Scheel Andreas, Schaefer Stephan C, Odenthal Margarete

Abstract excerpt

Accurate assessment of tumour heterogeneity is an important issue that influences prognosis and therapeutic decision in molecular pathology. Due to the shortage of protective histones and a limited DNA repair capacity, the mitochondrial (mt)-genome undergoes high variability during tumour development. Therefore, screening of mt-genome represents a useful molecular tool for assessing precise cell lineages and...

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Identifiers

PMID: 28894165
DOI: 10.1038/s41598-017-11345-3
PMCID: PMC5593826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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