Article
Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the region.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2017
Rajwani J, Klinger C M, Arango E, Arroyo M I, Sabbagh A, Maestre A, Dacks J B, Gnidehou S, Yanow S K
Abstract excerpt
Pregnancy-associated malaria (PAM) poses a threat to both the mother and fetus, increasing the risk of severe maternal anemia, fetal growth restriction and low birth weight infants. Two vaccines are currently in development to protect women from Plasmodium falciparum in pregnancy. Both vaccine constructs target the ID1-DBL2X domain of VAR2CSA, a protein expressed on the surface of infected erythrocytes (IEs) that...
Topics
- Adolescent
- Adult
- Antibodies, Protozoan
- Child
- Colombia
- Female
- Genetic Variation
- Genetics, Population
- Genotype
- Humans