Evaluating the genetic diversity of the Plasmodium vivax siap2 locus: A promising candidate for an effective malaria vaccine?

doi:10.1016/j.actatropica.2023.107111

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Article

Evaluating the genetic diversity of the Plasmodium vivax siap2 locus: A promising candidate for an effective malaria vaccine?

Acta tropica - 1 Mar 2024

Plata-Pineda Sergio E, Cárdenas-Munévar Laura X, Castro-Cavadía Carlos J, Buitrago Sindy P, Garzón-Ospina Diego

Abstract excerpt

Malaria is the deadliest parasitic disease in the world. Traditional control measures have become less effective; hence, there is a need to explore alternative strategies, such as antimalarial vaccines. However, designing an anti-Plasmodium vivax vaccine is considered a challenge due to the complex parasite biology and the antigens' high genetic diversity. Recently, the sporozoite invasion-associated protein 2...

Topics

Humans
Plasmodium vivax
Malaria Vaccines
Antigens, Protozoan
Protozoan Proteins
Genetic Variation
Malaria, Vivax
Selection, Genetic

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PMID: 38151069
DOI: 10.1016/j.actatropica.2023.107111

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