Article
A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.
eLife - 12 Sept 2017
Skene Nathan G, Roy Marcia, Grant Seth Gn
Abstract excerpt
The genetic mechanisms regulating the brain and behaviour across the lifespan are poorly understood. We found that lifespan transcriptome trajectories describe a calendar of gene regulatory events in the brain of humans and mice. Transcriptome trajectories defined a sequence of gene expression changes in neuronal, glial and endothelial cell-types, which enabled prediction of age from tissue samples. A major...
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