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Article

Alterations on high HbF levels may be associated with KLF1 gene mutations.

Cellular and molecular biology (Noisy-le-Grand, France) - 30 Aug 2017

Aydin M, Rencuzogullari E, Bayram S, Sevgiler Y, Genc A

Abstract excerpt

The KLF1 gene synthesizes a transcription factor in the zinc finger structure that regulates the transcription of β-, γ-globin, and Foxm1 genes. This factor plays an important role in the erythropoiesis mechanism by modifying the chromatin structure and is involved in the regulation of transcription in the opening of the β-globin gene. β-globin gene expression could be disrupted by a mutation, which may be a...

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Source

Identifiers

PMID: 28886314
DOI: 10.14715/KLF1; Fetal hemoglobin; Globin genes; Variations.

Genes

KLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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