Article
Melanoma tumor cell heterogeneity: a molecular approach to study subpopulations expressing the embryonic morphogen nodal.
Seminars in oncology - 1 Apr 2014
Seftor Elisabeth A, Seftor Richard E B, Weldon Don, Kirsammer Gina T, Margaryan Naira V, Gilgur Alina, Hendrix Mary J C
Abstract excerpt
As the frequency of melanoma increases, current treatment strategies are struggling to significantly impact patient survival. One of the critical issues in designing efficient therapies is understanding the composition of heterogeneous melanoma tumors in order to target cancer stem cells (CSCs) and drug-resistant subpopulations. In this review, we summarize recent findings pertinent to the reemergence of the...
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