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Article

Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors.

Nature communications - 7 Sept 2017

Martin-Trujillo Alex, Vidal Enrique, Monteagudo-Sánchez Ana, Sanchez-Delgado Marta, Moran Sebastian, Hernandez Mora Jose Ramon, Heyn Holger, Guitart Miriam, Esteller Manel, Monk David

Abstract excerpt

It has been postulated that imprinting aberrations are common in tumors. To understand the role of imprinting in cancer, we have characterized copy-number and methylation in over 280 cancer cell lines and confirm our observations in primary tumors. Imprinted differentially methylated regions (DMRs) regulate parent-of-origin monoallelic expression of neighboring transcripts in cis. Unlike single-copy CpG islands...

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Share to DNA Copy Number Variations
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Dosage

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Loci

Share to Genomic Imprinting

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 28883545
DOI: 10.1038/s41467-017-00639-9
PMCID: PMC5589900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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