Article
Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.
BMC cancer - 27 Dec 2013
Rumbajan Janette Mareska, Maeda Toshiyuki, Souzaki Ryota, Mitsui Kazumasa, Higashimoto Ken, Nakabayashi Kazuhiko, Yatsuki Hitomi, Nishioka Kenichi, Harada Ryoko, Aoki Shigehisa, Kohashi Kenichi, Oda Yoshinao, Hata Kenichiro, Saji Tsutomu, Taguchi Tomoaki, Tajiri Tatsuro, Soejima Hidenobu, Joh Keiichiro
Abstract excerpt
BACKGROUND: Aberrant methylation at imprinted differentially methylated regions (DMRs) in human 11p15.5 has been reported in many tumors including hepatoblastoma. However, the methylation status of imprinted DMRs in imprinted loci scattered through the human genome has not been analyzed yet in any tumors. METHODS: The methylation statuses of 33 imprinted DMRs were analyzed in 12 hepatoblastomas and adjacent...
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