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Article

Altered methylation of imprinted genes in neuroblastoma: implications for prognostic refinement.

Journal of translational medicine - 31 Aug 2024

Suman Medha, Löfgren Maja, Fransson Susanne, Yousuf Jewahri Idris, Svensson Johanna, Djos Anna, Martinsson Tommy, Kogner Per, Kling Teresia, Carén Helena

Abstract excerpt

BACKGROUND: Neuroblastoma (NB) is a complex disease, and the current understanding of NB biology is limited. Deregulation in genomic imprinting is a common event in malignancy. Since imprinted genes play crucial roles in early fetal growth and development, their role in NB pathogenesis could be suggested. METHODS: We examined alterations in DNA methylation patterns of 369 NB tumours at 49 imprinted differentially...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 39217334
DOI: 10.1186/s12967-024-05634-5
PMCID: PMC11366169

Genes

NNAT
BLCAP
MAGEL2
RB1
MKRN3
MYCN
HTR5A
IGF2
INPP5F
NDN
SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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