Article
Biflorin induces cytotoxicity by DNA interaction in genetically different human melanoma cell lines.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Aug 2016
Ralph Ana Carolina Lima, Calcagno Danielle Queiroz, da Silva Souza Luciana Gregório, de Lemos Telma Leda Gomes, Montenegro Raquel Carvalho, de Arruda Cardoso Smith Marília, de Vasconcellos Marne Carvalho
Abstract excerpt
Cancer is a public health problem and the second leading cause of death worldwide. The incidence of cutaneous melanoma has been notably increasing, resulting in high aggressiveness and poor survival rates. Taking into account the antitumor activity of biflorin, a substance isolated from Capraria biflora L. roots that is cytotoxic in vitro and in vivo, this study aimed to demonstrate the action of biflorin against...
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