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Article

Alternative pathways for radical dissipation in an active site mutant of B12-dependent methylmalonyl-CoA mutase.

Biochemistry - 7 Mar 2006

Padovani Dominique, Banerjee Ruma

Abstract excerpt

Methylmalonyl-CoA mutase catalyzes the adenosylcobalamin-dependent rearrangement of (2R)-methylmalonyl-CoA to succinyl-CoA. The crystal structure of the enzyme reveals that Y243 is in van der Waals contact with the methyl group of the substrate and suggests a possible role for it in the stereochemical control of the reaction. This hypothesis was tested by designing a molecular hole by replacing the phenolic side...

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Identifiers

PMID: 16503649
DOI: 10.1021/bi051742d
PMCID: PMC3190604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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