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miCLIP-MaPseq Identifies Substrates of Radical SAM RNA-Methylating Enzyme Using Mechanistic Cross-Linking and Mismatch Profiling.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Stojković Vanja, Weinberg David E, Fujimori Danica Galonić

Abstract excerpt

The family of radical SAM RNA-methylating enzymes comprises a large group of proteins that contains only a few functionally characterized members. Several enzymes in this family have been implicated in the regulation of translation and antibiotic susceptibility, emphasizing their significance in bacterial physiology and their relevance to human health. While few characterized enzymes have been shown to modify...

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PMID: 34085241
DOI: 10.1007/978-1-0716-1374-0_7
PMCID: PMC8245296

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