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Article

Novel GP64 envelope variants for improved delivery to human airway epithelial cells.

Gene therapy - 1 Oct 2017

Sinn P L, Hwang B-Y, Li N, Ortiz J L S, Shirazi E, Parekh K R, Cooney A L, Schaffer D V, McCray P B

Abstract excerpt

Lentiviral vectors pseudotyped with the baculovirus envelope protein GP64 transduce primary cultures of human airway epithelia (HAE) at their apical surface. Our goal in this study was to harness a directed evolution approach to develop a novel envelope glycoprotein with increased transduction properties for HAE. Using error-prone PCR, a library of GP64 mutants was generated and used to prepare a diverse pool of...

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Identifiers

PMID: 28880020
DOI: 10.1038/gt.2017.78
PMCID: PMC5759328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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