Article
Lentiviral vectors pseudotyped with minimal filovirus envelopes increased gene transfer in murine lung.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Nov 2003
Medina Maria Fe, Kobinger Gary P, Rux John, Gasmi Mehdi, Looney David J, Bates Paul, Wilson James M
Abstract excerpt
A human immunodeficiency virus (HIV)-based vector pseudotyped with the Ebola Zaire (EboZ) viral envelope glycoprotein (GP) was recently shown to transduce murine airway epithelia cells in vivo. In this study, the vector was further redesigned to improve gene transfer and also to increase safety. We used mutant EboZ envelopes for pseudotyping, which resulted in higher titers and increased transduction of airway...
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