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A Receptor-targeted Nanocomplex Vector System Optimized for Respiratory Gene Transfer

3 Apr 2008

Abstract excerpt

Synthetic vectors for cystic fibrosis (CF) gene therapy are required that efficiently and safely transfect airway epithelial cells, rather than alveolar epithelial cells or macrophages, and that are nonimmunogenic, thus allowing for repeated delivery. We have compared several vector systems against these criteria including GL67, polyethylenimine (PEI) 22 and 25 kd and two new, synthetic vector formulations,...

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PMID: 18388925
DOI: 10.1038/mt.2008.38

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