Article
Directed evolution of adeno-associated virus to an infectious respiratory virus.
Proceedings of the National Academy of Sciences of the United States of America - 10 Mar 2009
Excoffon Katherine J D A, Koerber James T, Dickey David D, Murtha Matthew, Keshavjee Shaf, Kaspar Brian K, Zabner Joseph, Schaffer David V
Abstract excerpt
Respiratory viruses evolve to maintain infectivity levels that permit spread yet prevent host and virus extinction, resulting in surprisingly low infection rates. Respiratory viruses harnessed as gene therapy vectors have illustrated this limitation. We used directed evolution in an organotypic human airway model to generate a highly infectious adeno-associated virus. This virus mediated gene transfer more than...
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